
Author: IctalGroup
Spectrum of neurological manifestations associated with SARS-CoV-2 infection

All neurological manifestations
- UK-wide surveillance of neurological and neuropsychiatric complications of COVID19 the first 153 patients. Preprint
- Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology 2020
- New onset neurologic events in people with COVID-19 infection in three regions in China. Neurology 2020
- An Italian multicenter retrospective-prospective observational study on neurological manifestations of COVID-19 (NEUROCOVID). Neurol Sci 2020
Acute Encephalopathy :
- Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study preprint 2020 or same here JAMA Neurology 2020
- Neurologic Features in Severe SARS-CoV-2 Infection NEJM 2020
- Concomitant neurological symptoms observed in a patient diagnosed with coronavirus disease 2019. J Med Virol 2020
- Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy. Cureus 2020
- Encephalopathy in Patients With COVID-19: ‘Causality or Coincidence?’. J Med Virol 2020
- Involvement and Altered Mental Status: A Unique Neurological Manifestation of Coronavirus Disease 2019. Cureus 2020
- COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. Neurol Neuroimmunol Neuroinflamm 2020
- Acute necrotizing encephalopathy and myocarditis in a young patient with COVID-19. Neurol Neuroimmunol Neuroinflamm 2020
- Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020
Anti-NMDA receptor encephalitis
Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: A case report. Brain, Behavior, and Immunity 2020
Seizures / Status Epilepticus / Myoclonus / EEG findings
- New‐onset acute symptomatic seizure and risk factors in Corona Virus Disease 2019: A Retrospective Multicenter Study. Epilepsia 2020
- Focal status epilepticus as unique clinical feature of COVID-19: a case report. Seizure 2020
- Non-lesional Status Epilepticus in a Patient With Coronavirus Disease 2019. Clinical Neurophysiol 2020
- De Novo Status Epilepticus in Patients With COVID-19. Ann Clin Transl Neurol 2020
- Generalized myoclonus in COVID-19. Neurology 2020
- Pay more attention to EEG in COVID-19 pandemic. Clinical Neurophysiology 2020
- Continuous Electroencephalography (cEEG) Characteristics and AcuteSymptomatic Seizures in COVID-19 Patients. Preprint
- Report of EEG Finding on Critically Ill Patients with COVID ‐19. Annals of Neurology 2020
- EEG Findings in Acutely Ill Patients Investigated for SARS-CoV-2/COVID-19: A Small Case Series Preliminary Report. Epilepsia open 2020
Acute Hemorrhagic Necrotizing Encephalopathy :
- COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features Radiology 2020
Ischemic Stroke / Intra Cerebral Hemorrhage / Cerebral Venous Sinus Thrombosis :
- Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study preprint 2020 or same here JAMA Neurology 2020
- Acute Cerebrovascular Disease Following COVID-19: A Single Center, Retrospective, Observational Study preprint Lancet 2020
- Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 NEJM 2020
- Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis Research 2020
- High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Medicine 2020
- Cerebrovascular complications in patients with SARS-CoV-2 infection: Case series.
- Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature. International Journal of Stroke 2020
- COVID-19 and intracerebral haemorrhage: causative or coincidental? New Microbes and New Infections 2020
- Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. NEJM 2020
- Characteristics of ischaemic stroke associated with COVID-19. JNNP 2020
- Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke. JNNP 2020
- Emergency Room Neurology in times of COVID‐19: Malignant Ischemic Stroke and SARS‐COV2 Infection. European Journal of Neurology 2020
- Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Ischemic Stroke. Stroke 2020
- Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection. Journal of Neuroradiology 2020
- Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection. Radiology 2020
- COVID-19 –associated Diffuse Leukoencephalopathy and Microhemorrhages. Radiology 2020
- COVID-19 presenting as stroke. Brain Behav Immun 2020
- Emergency Room Neurology in times of COVID-19: Malignant Ischemic Stroke and SARS-COV2 Infection. Eur J Neurol 2020
- Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci 2020
- Perioperative and Critical Care Management of a Patient With Severe Acute Respiratory Syndrome Corona Virus 2 Infection and Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2020
- Thalamic perforating artery stroke on computed tomography perfusion in a patient with coronavirus disease 2019. Journal of Stroke and Cerebrovascular diseases 2020
- Acute Cerebral Stroke With Multiple Infarctions and COVID-19, France, 2020. Emerg Infect Dis 2020
- Arterial and Venous Thromboembolic Disease in a Patient With COVID-19: A Case Report. Thromb Res 2020
- Cerebrovascular disease in patients with COVID-19 neuroimaging, histological and clinical description. Brain 2020
Encephalitis
- A first Case of Meningitis/Encephalitis associated withSARS-Coronavirus-2 International Journal of Infectious Diseases 2020
- Meningoencephalitis without respiratory failure in a young female patient with COVID-19 infection in Downtown Los Angeles, early April 2020. Brain, Behavior and Immunity 2020
- Steroid‐responsive encephalitis in Covid‐19 disease. Annals of neurology 2020.
- Two patients with acute meningoencephalitis concomitant with SARS‐CoV‐2 infection. Eur J Neurol 2020
Demyelinating lesions
- SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir 2020
- COVID-19-White matter and globus pallidum lesions: Demyelination or small-vesselvasculitis? Neurol Neuroimmunol Neuroinflamm 2020
- First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease. J Neurol 2020
ADEM
- Acute disseminated encephalomyelitis after SARS-CoV-2 infection. Neurology Neurol Neuroimmunol Neuroinflamm 2020
- The association of SARS-CoV-2 infection and acute disseminated encephalomyelitis without prominent clinical pulmonary symptoms. Journal of Neurological sciences 2020
Myelitis
- COVID-19-associated acute necrotizing myelitis. Neurology 2020
Guillain-Barré Syndrome / Miller Fisher Syndrome
- Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurology 2020
- Guillain–Barré Syndrome Associated with SARS-CoV-2. NEJM 2020
- Guillain Barre syndrome associated with COVID-19 infection: A case report. Journal of Clinical Neuroscience 2020
- Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. Neurology 2020
- Guillain-Barre syndrome during SARS-CoV-2 pandemic: a case report and review of recent literature. J Peripher Nerv Syst 2020
- Covid-19 and Guillain-Barré syndrome: More than a coincidence! Rev Neurol 2020
- Guillain-Barré syndrome related to COVID-19 infection. Neurol Neuroimmunol Neuroinflamm 2020
- COVID-19 may induce Guillain-Barré syndrome. Rev Neurol 2020
- Guillain-Barré syndrome following COVID-19: new infection, old complication? J Neurol 2020
- Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2. Journal of Clinical Neuroscience 2020
- Guillain-Barré Syndrome associated with the coronavirus disease 2019 (COVID-19). Neurology 2020
Posterior Reversible Encephalopathy Syndrome
- Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: Case report. J Neurol Sci 2020
- Hemorrhagic Posterior Reversible Encephalopathy Syndrome as a Manifestation of COVID-19 Infection. AJNR 2020
- Posterior Reversible Encephalopathy Syndrome (PRES) as a Neurological Association in Severe Covid-19. J Neurol Sci 2020
- SARS‐CoV‐2 and Guillain‐Barré syndrome: AIDP variant with favorable outcome. Eur J Neurol 2020
- Reversible Encephalopathy Syndrome (PRES) in a COVID‑19 patient. J Neurol 2020
Subjective neurological symptoms
- Subjective Neurological Symptoms Frequently Occur in Patients With SARS-CoV2 Infection. Brain Behav Immun 2020
Postmortem positive or negative findings
- Postmortem Examination of Patients With COVID-19. JAMA 2020
- Early postmortem brain MRI findings in COVID-19 non-survivors. Preprint
- Early evidence of pronounced brain involvement in fatal COVID-19 outcomes. Lancet 2020
- Neuropathological Features of Covid-19. NEJM 2020
Imaging findings
Biomarkers of CNS injury
Management complications
Hypothermia as a treatment in status epilepticus: A narrative review
Critical Care EEG Course
Knowledge of the basic fundamental skills of electroencephalography would enable medical and nursing staffs to provide efficient and effective bedside EEG monitoring in critically ill patients.
The aim of this study is to evaluate the ability of a 10-points EEG teaching program to allow bedside caregivers (medical and nursing intensive care unit staff) interpreting EEG in the critical care setting (#NCT03545776).
Participants are volunteers among medical and nursing ICU staff of the participating ICUs, excluding experienced or trained ICU staff members to EEG interpretation (pre-test score > 5/10).
Educational program : Medical and nursing staff will be given a 10-points EEG face-to-face initial training course that will be preceded by a pre-test evaluation and followed by delayed post-test evaluations. Training will be followed by an online teaching consisting on additional questions and answers quizzes based on the 10 following educational goals.
10-points EEG educational objectives : physiological rhythms, reactivity, symmetry, effects of sedation, burst suppression, paroxysmal activities, periodic / pseudoperiodic activities, rhythmic activities, artifacts, null EEG
In order to avoid any risk of intrasite contamination, all the learners benefiting from the training in the same department will be trained in a uniform time, with respect to the training schedule regarding post-test evaluations (day-1, day-15 and day-30). A final evaluation will be performed at day-90 after beginning of the training course.
First outcome is overall EEG interpretation at Day 90 as defined by percentage of learners with a correct answer rate. Training will be considered as efficient if more than 75% of learners are associated with a correct answer rate above 80% to EEG interpretation test at day 90 after initial training.
Secondary outcomes are before/after comparison of correct answer rate between pre-test and post-tests evaluations at day 1, day 15, day 30 and day 90 after face-to-face training. Analyzes will be carried out according to each of the 10-points educational goals, according to the medical or nursing staff category, according to the student’s degree and according to the center and to usual way of using EEG (continuous, sequential, external provider)